Computed·Blg

Via University of Washington

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Yan Liang, L2XY2.com

An example of a chemical program. Here, A, B and C are different chemical species.

Similar to using Python or Java to write code for a computer, chemists soon could be able to use a structured set of instructions to “program” how DNA molecules interact in a test tube or cell.

A team led by the University of Washington has developed a programming language for chemistry that it hopes will streamline efforts to design a network that can guide the behavior of chemical-reaction mixtures in the same way that embedded electronic controllers guide cars, robots and other devices. In medicine, such networks could serve as “smart” drug deliverers or disease detectors at the cellular level.

The findings were published online this week (Sept. 29) in Nature Nanotechnology.

Chemists and educators teach and use chemical reaction networks, a century-old language of equations that describes how mixtures of chemicals behave. The UW engineers take this language a step further and use it to write programs that direct the movement of tailor-made molecules.

“We start from an abstract, mathematical description of a chemical system, and then use DNA to build the molecules that realize the desired dynamics,” said corresponding author Georg Seelig, a UW assistant professor of electrical engineering and of computer science and engineering. “The vision is that eventually, you can use this technology to build general-purpose tools.”

Currently, when a biologist or chemist makes a certain type of molecular network, the engineering process is complex, cumbersome and hard to repurpose for building other systems. The UW engineers wanted to create a framework that gives scientists more flexibility. Seelig likens this new approach to programming languages that tell a computer what to do.

“I think this is appealing because it allows you to solve more than one problem,” Seelig said. “If you want a computer to do something else, you just reprogram it. This project is very similar in that we can tell chemistry what to do.”

Humans and other organisms already have complex networks of nano-sized molecules that help to regulate cells and keep the body in check. Scientists now are finding ways to design synthetic systems that behave like biological ones with the hope that synthetic molecules could support the body’s natural functions. To that end, a system is needed to create synthetic DNA molecules that vary according to their specific functions.

The new approach isn’t ready to be applied in the medical field, but future uses could include using this framework to make molecules that self-assemble within cells and serve as “smart” sensors. These could be embedded in a cell, then programmed to detect abnormalities and respond as needed, perhaps by delivering drugs directly to those cells.

Seelig and colleague Eric Klavins, a UW associate professor of electrical engineering, recently received $2 million from the National Science Foundation as part of a national initiative to boost research in molecular programming. The new language will be used to support that larger initiative, Seelig said.

Co-authors of the paper are Yuan-Jyue Chen, a UW doctoral student in electrical engineering; David Soloveichik of the University of California, San Francisco; Niranjan Srinivas at the California Institute of Technology; and Neil Dalchau, Andrew Phillips and Luca Cardelli of Microsoft Research.

The research was funded by the National Science Foundation, the Burroughs Wellcome Fund and the National Centers for Systems Biology.

Via The Verge

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For years, scientists have struggled to collect accurate real-time data on earthquakes, but a new article published today in the Bulletin of the Seismological Society of America may have found a better tool for the job, using the same accelerometers found in most modern smartphones. The article finds that the MEMS accelerometers in current smartphones are sensitive enough to detect earthquakes of magnitude five or higher when located near the epicenter. Because the devices are so widely used, scientists speculate future smartphone models could be used to create an "urban seismic network," transmitting real-time geological data to authorities whenever a quake takes place.

The authors pointed to Stanford's Quake-Catcher Network as an inspiration, which connects seismographic equipment to volunteer computers to create a similar network. But using smartphone accelerometers would be cheaper and easier to carry into extreme environments. The sensor will need to become more sensitive before it can be used in the field, but the authors say once technology catches up, a smartphone accelerometer could be the perfect earthquake research tool. As one researcher told The Verge, "right from the start, this technology seemed to have all the requirements for monitoring earthquakes — especially in extreme environments, like volcanoes or underwater sites."