Computed·Blg

Via The New York Times

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Via Slash Gear

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We’ve been hearing a lot about Google‘s self-driving car lately, and we’re all probably wanting to know how exactly the search giant is able to construct such a thing and drive itself without hitting anything or anyone. A new photo has surfaced that demonstrates what Google’s self-driving vehicles see while they’re out on the town, and it looks rather frightening.

The image was tweeted by Idealab founder Bill Gross, along with a claim that the self-driving car collects almost 1GB of data every second (yes, every second). This data includes imagery of the cars surroundings in order to effectively and safely navigate roads. The image shows that the car sees its surroundings through an infrared-like camera sensor, and it even can pick out people walking on the sidewalk.

Of course, 1GB of data every second isn’t too surprising when you consider that the car has to get a 360-degree image of its surroundings at all times. The image we see above even distinguishes different objects by color and shape. For instance, pedestrians are in bright green, cars are shaped like boxes, and the road is in dark blue.

However, we’re not sure where this photo came from, so it could simply be a rendering of someone’s idea of what Google’s self-driving car sees. Either way, Google says that we could see self-driving cars make their way to public roads in the next five years or so, which actually isn’t that far off, and Tesla Motors CEO Elon Musk is even interested in developing self-driving cars as well. However, they certainly don’t come without their problems, and we’re guessing that the first batch of self-driving cars probably won’t be in 100% tip-top shape.

Via Slash Gear

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IBM has developed a light-based data transfer system delivering more than 25Gbps per channel, opening the door to chip-dense slabs of processing power that could speed up server performance, the internet, and more. The company’s research into silicon integrated nanophotonics addresses concerns that interconnects between increasingly powerful computers, such as mainframe servers, are unable to keep up with the speeds of the computers themselves. Instead of copper or even optical cables, IBM envisages on-chip optical routing, where light blasts data between dense, multi-layer computing hubs.

“This future 3D-integated chip consists of several layers connected with each other with very dense and small pitch interlayer vias. The lower layer is a processor itself with many hundreds of individual cores. Memory layer (or layers) are bonded on top to provide fast access to local caches. On top of the stack is the Photonic layer with many thousands of individual optical devices (modulators, detectors, switches) as well as analogue electrical circuits (amplifiers, drivers, latches, etc.). The key role of a photonic layer is not only to provide point-to-point broad bandwidth optical link between different cores and/or the off-chip traffic, but also to route this traffic with an array of nanophotonic switches. Hence it is named Intra-chip optical network (ICON)” IBM

Optical interconnects are increasingly being used to link different server nodes, but by bringing the individual nodes into a single stack the delays involved in communication could be pared back even further. Off-chip optical communications would also be supported, to link the data-rich hubs together.

Although the photonics system would be considerably faster than existing links – it supports multiplexing, joining multiple 25Gbps+ connections into one cable thanks to light wavelength splitting – IBM says it would also be cheaper thanks to straightforward manufacturing integration:

“By adding a few processing modules into a high-performance 90nm CMOS fabrication line, a variety of silicon nanophotonics components such as wavelength division multiplexers (WDM), modulators, and detectors are integrated side-by-side with a CMOS electrical circuitry. As a result, single-chip optical communications transceivers can be manufactured in a conventional semiconductor foundry, providing significant cost reduction over traditional approaches” IBM

Technologies like the co-developed Thunderbolt from Intel and Apple have promised affordable light-based computing connections, but so far rely on more traditional copper-based links with optical versions further down the line. IBM says its system is “primed for commercial development” though warns it may take a few years before products could actually go on sale.

Via engadget

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Spoiler alert: a reoccurring cast member bids farewell in the latest James Bond flick. When the production of Skyfall called for the complete decimation of a classic 1960s era Aston Martin DB5, filmmakers opted for something a little more lifelike than computer graphics. The movie studio contracted the services of Augsburg-based 3D printing company Voxeljet to make replicas of the vintage ride. Skipping over the residential-friendly MakerBot Replicator, the company used a beastly industrial VX4000 3D printer to craft three 1:3 scale models of the car with a plot to blow them to smithereens. The 18 piece miniatures were shipped off to Propshop Modelmakers in London to be assembled, painted, chromed and outfitted with fake bullet holes. The final product was used in the film during a high-octane action sequence, which resulted in the meticulously crafted prop receiving a Wile E. Coyote-like sendoff. Now, rest easy knowing that no real Aston Martins were harmed during the making of this film. Head past the break to get a look at a completed model prior to its untimely demise.

Via dvice

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What happens when you combine advances in 3D printing with biosynthesis and molecular construction? Eventually, it might just lead to printers that can manufacture vaccines and other drugs from scratch: email your doc, download some medicine, print it out and you're cured.

This concept (which is surely being worked on as we speak) comes from Craig Venter, whose idea of synthesizing DNA on Mars we posted about last week. You may remember a mention of the possibility of synthesizing Martian DNA back here on Earth, too: Venter says that we can do that simply by having the spacecraft email us genetic information on whatever it finds on Mars, and then recreate it in a lab by mixing together nucleotides in just the right way. This sort of thing has already essentially been done by Ventner, who created the world's first synthetic life form back in 2010.

Vetner's idea is to do away with complex, expensive and centralized vaccine production and instead just develop one single machine that can "print" drugs by carefully combining nucleotides, sugars, amino acids, and whatever else is needed while u wait. Technology like this would mean that vaccines could be produced locally, on demand, simply by emailing the appropriate instructions to your closes drug printer. Pharmacies would no longer consists of shelves upon shelves of different pills, but could instead be kiosks with printers inside them. Ultimately, this could even be something you do at home.

While the benefits to technology like this are obvious, the risks are equally obvious. I mean, you'd basically be introducing the Internet directly into your body. Just ingest that for a second and think about everything that it implies. Viruses. LOLcats. Rule 34. Yeah, you know what, maybe I'll just stick with modern American healthcare and making ritual sacrifices to heathen gods, at least one of which will probably be effective.

Silas R. Beane, Zohreh Davoudi, Martin J. Savage

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Observable consequences of the hypothesis that the observed universe is a numerical simulation performed on a cubic space-time lattice or grid are explored. The simulation scenario is first motivated by extrapolating current trends in computational resource requirements for lattice QCD into the future. Using the historical development of lattice gauge theory technology as a guide, we assume that our universe is an early numerical simulation with unimproved Wilson fermion discretization and investigate potentially-observable consequences. Among the observables that are considered are the muon g-2 and the current differences between determinations of alpha, but the most stringent bound on the inverse lattice spacing of the universe, b^(-1) >~ 10^(11) GeV, is derived from the high-energy cut off of the cosmic ray spectrum. The numerical simulation scenario could reveal itself in the distributions of the highest energy cosmic rays exhibiting a degree of rotational symmetry breaking that reflects the structure of the underlying lattice.

PDF

Via TechHive

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The iPhone 5 is the latest smartphone to hop on-board the LTE (Long Term Evolution) bandwagon, and for good reason: The mobile broadband standard is fast, flexible, and designed for the future. Yet LTE is still a young technology, full of growing pains. Here’s an overview of where it came from, where it is now, and where it might go from here.

The evolution of ‘Long Term Evolution’

LTE is a mobile broadband standard developed by the 3GPP (3rd Generation Partnership Project), a group that has developed all GSM standards since 1999. (Though GSM and CDMA—the network Verizon and Sprint use in the United States—were at one time close competitors, GSM has emerged as the dominant worldwide mobile standard.)

Cell networks began as analog, circuit-switched systems nearly identical in function to the public switched telephone network (PSTN), which placed a finite limit on calls regardless of how many people were speaking on a line at one time.

The second-generation, GPRS, added data (at dial-up modem speed). GPRS led to EDGE, and then 3G, which treated both voice and data as bits passing simultaneously over the same network (allowing you to surf the web and talk on the phone at the same time).

GSM-evolved 3G (which brought faster speeds) started with UMTS, and then accelerated into faster and faster variants of 3G, 3G+, and “4G” networks (HSPA, HSDPA, HSUPA, HSPA+, and DC-HSPA).

Until now, the term “evolution” meant that no new standard broke or failed to work with the older ones. GSM, GPRS, UMTS, and so on all work simultaneously over the same frequency bands: They’re intercompatible, which made it easier for carriers to roll them out without losing customers on older equipment. But these networks were being held back by compatibility.

That’s where LTE comes in. The “long term” part means: “Hey, it’s time to make a big, big change that will break things for the better.”

LTE needs its own space, man

LTE has “evolved” beyond 3G networks by incorporating new radio technology and adopting new spectrum. It allows much higher speeds than GSM-compatible standards through better encoding and wider channels. (It’s more “spectrally efficient,” in the jargon.)

LTE is more flexible than earlier GSM-evolved flavors, too: Where GSM’s 3G variants use 5 megahertz (MHz) channels, LTE can use a channel size from 1.4 MHz to 20 MHz; this lets it work in markets where spectrum is scarce and sliced into tiny pieces, or broadly when there are wide swaths of unused or reassigned frequencies. In short, the wider the channel—everything else being equal—the higher the throughput.

Speeds are also boosted through MIMO (multiple input, multiple output), just as in 802.11n Wi-Fi. Multiple antennas allow two separate benefits: better reception, and multiple data streams on the same spectrum.

LTE complications

Unfortunately, in practice, LTE implementation gets sticky: There are 33 potential bands for LTE, based on a carrier’s local regulatory domain. In contrast, GSM has just 14 bands, and only five of those are widely used. (In broad usage, a band is two sets of paired frequencies, one devoted to upstream traffic and the other committed to downstream. They can be a few MHz apart or hundreds of MHz apart.)

And while LTE allows voice, no standard has yet been agreed upon; different carriers could ultimately choose different approaches, leaving it to handset makers to build multiple methods into a single phone, though they’re trying to avoid that. In the meantime, in the U.S., Verizon and AT&T use the older CDMA and GSM networks for voice calls, and LTE for data.

LTE in the United States

Of the four major U.S. carriers, AT&T, Verizon, and Sprint have LTE networks, with T-Mobile set to start supporting LTE in the next year. But that doesn’t mean they’re set to play nice. We said earlier that current LTE frequencies are divided up into 33 spectrum bands: With the exception of AT&T and T-Mobile, which share frequencies in band 4, each of the major U.S. carriers has its own band. Verizon uses band 13; Sprint has spectrum in band 26; and AT&T holds band 17 in addition to some crossover in band 4.

In addition, smaller U.S. carriers, like C Spire, U.S. Cellular, and Clearwire, all have their own separate piece of the spectrum pie: C Spire and U.S. Cellular use band 12, while Clearwire uses band 41.

As such, for a manufacturer to support LTE networks in the United States alone, it would need to build a receiver that could tune into seven different LTE bands—let alone the various flavors of GSM-evolved or CDMA networks.

With the iPhone, Apple tried to cut through the current Gordian Knot by releasing two separate models, the A1428 and A1429, which cover a limited number of different frequencies depending on where they’re activated. (Apple has kindly released a list of countries that support its three iPhone 5 models.) Other companies have chosen to restrict devices to certain frequencies, or to make numerous models of the same phone.

Banded together

Other solutions are coming. Qualcomm made a regulatory filing in June regarding a seven-band LTE chip, which could be in shipping devices before the end of 2012 and could allow a future iPhone to be activated in different fashions. Within a year or so, we should see most-of-the-world phones, tablets, and other LTE mobile devices that work on the majority of large-scale LTE networks.

That will be just in time for the next big thing: LTE-Advanced, the true fulfillment of what was once called 4G networking, with rates that could hit 1 Gbps in the best possible cases of wide channels and short distances. By then, perhaps the chip, handset, and carrier worlds will have converged to make it all work neatly together.

Via PLOS genetics

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Abstract

Inter-individual variation in facial shape is one of the most noticeable phenotypes in humans, and it is clearly under genetic regulation; however, almost nothing is known about the genetic basis of normal human facial morphology. We therefore conducted a genome-wide association study for facial shape phenotypes in multiple discovery and replication cohorts, considering almost ten thousand individuals of European descent from several countries. Phenotyping of facial shape features was based on landmark data obtained from three-dimensional head magnetic resonance images (MRIs) and two-dimensional portrait images. We identified five independent genetic loci associated with different facial phenotypes, suggesting the involvement of five candidate genes—PRDM16, PAX3, TP63, C5orf50, and COL17A1—in the determination of the human face. Three of them have been implicated previously in vertebrate craniofacial development and disease, and the remaining two genes potentially represent novel players in the molecular networks governing facial development. Our finding at PAX3 influencing the position of the nasion replicates a recent GWAS of facial features. In addition to the reported GWA findings, we established links between common DNA variants previously associated with NSCL/P at 2p21, 8q24, 13q31, and 17q22 and normal facial-shape variations based on a candidate gene approach. Overall our study implies that DNA variants in genes essential for craniofacial development contribute with relatively small effect size to the spectrum of normal variation in human facial morphology. This observation has important consequences for future studies aiming to identify more genes involved in the human facial morphology, as well as for potential applications of DNA prediction of facial shape such as in future forensic applications.

Introduction

The morphogenesis and patterning of the face is one of the most complex events in mammalian embryogenesis. Signaling cascades initiated from both facial and neighboring tissues mediate transcriptional networks that act to direct fundamental cellular processes such as migration, proliferation, differentiation and controlled cell death. The complexity of human facial development is reflected in the high incidence of congenital craniofacial anomalies, and almost certainly underlies the vast spectrum of subtle variation that characterizes facial appearance in the human population.

Facial appearance has a strong genetic component; monozygotic (MZ) twins look more similar than dizygotic (DZ) twins or unrelated individuals. The heritability of craniofacial morphology is as high as 0.8 in twins and families [1], [2], [3]. Some craniofacial traits, such as facial height and position of the lower jaw, appear to be more heritable than others [1], [2], [3]. The general morphology of craniofacial bones is largely genetically determined and partly attributable to environmental factors [4]–[11]. Although genes have been mapped for various rare craniofacial syndromes largely inherited in Mendelian form [12], the genetic basis of normal variation in human facial shape is still poorly understood. An appreciation of the genetic basis of facial shape variation has far reaching implications for understanding the etiology of facial pathologies, the origin of major sensory organ systems, and even the evolution of vertebrates [13], [14]. In addition, it is feasible to speculate that once the majority of genetic determinants of facial morphology are understood, predicting facial appearance from DNA found at a crime scene will become useful as investigative tool in forensic case work [15]. Some externally visible human characteristics, such as eye color [16]–[18] and hair color [19], can already be inferred from a DNA sample with practically useful accuracies.

In a recent candidate gene study carried out in two independent European population samples, we investigated a potential association between risk alleles for non-syndromic cleft lip with or without cleft palate (NSCL/P) and nose width and facial width in the normal population [20]. Two NSCL/P associated single nucleotide polymorphisms (SNPs) showed association with different facial phenotypes in different populations. However, facial landmarks derived from 3-Dimensional (3D) magnetic resonance images (MRI) in one population and 2-Dimensional (2D) portrait images in the other population were not completely comparable, posing a challenge for combining phenotype data. In the present study, we focus on the MRI-based approach for capturing facial morphology since previous facial imaging studies by some of us have demonstrated that MRI-derived soft tissue landmarks represent a reliable data source [21], [22].

In geometric morphometrics, there are different ways to deal with the confounders of position and orientation of the landmark configurations, such as (1) superimposition [23], [24] that places the landmarks into a consensus reference frame; (2) deformation [25]–[27], where shape differences are described in terms of deformation fields of one object onto another; and (3) linear distances [28], [29], where Euclidean distances between landmarks instead of their coordinates are measured. Rationality and efficacy of these approaches have been reviewed and compared elsewhere [30]–[32]. We briefly compared these methods in the context of our genome-wide association study (GWAS) (see Methods section) and applied them when appropriate.

We extracted facial landmarks from 3D head MRI in 5,388 individuals of European origin from Netherlands, Australia, and Germany, and used partial Procrustes superimposition (PS) [24], [30], [33] to superimpose different sets of facial landmarks onto a consensus 3D Euclidean space. We derived 48 facial shape features from the superimposed landmarks and estimated their heritability in 79 MZ and 90 DZ Australian twin pairs. Subsequently, we conducted a series of GWAS separately for these facial shape dimensions, and attempted to replicate the identified associations in 568 Canadians of European (French) ancestry with similar 3D head MRI phenotypes and additionally sought supporting evidence in further 1,530 individuals from the UK and 2,337 from Australia for whom facial phenotypes were derived from 2D portrait images.

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The full article@PLOS genetics

Via Motherboard

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Wearable computing is all the rage this year as Google pulls back the curtain on their Glass technology, but some scientists want to take the idea a stage further. The emerging field of stretchable electronics is taking advantage of new polymers that allow you to not just wear your computer but actually become a part of the circuitry. By embedding the wiring into a stretchable polymer, these cutting edge devices resemble human skin more than they do circuit boards. And with a whole host of possible medical uses, that’s kind of the point.

A Cambridge, Massachusetts startup called MC10 is leading the way in stretchable electronics. So far, their products are fairly simple. There’s a patch that’s meant to be installed right on the skin like a temporary tattoo that can sense whether or not the user is hydrated as well as an inflatable balloon catheter that can measure the electronic signals of the user’s heartbeat to search for irregularities like arrythmias. Later this year, they’re launching a mysterious product with Reebok that’s expected to take advantage of the technology’s ability to detect not only heartbeat but also respiration, body temperature, blood oxygenation and so forth.

The joy of stretchable electronics is that the manufacturing process is not unlike that of regular electronics. Just like with a normal microchip, gold electrodes and wires are deposited on to thin silicone wafers, but they’re also embedded in the stretchable polymer substrate. When everything’s in place, the polymer substrate with embedded circuitry can be peeled off and later installed on a new surface. The components that can be added to stretchable surface include sensors, LEDs, transistors, wireless antennas and solar cells for power.

For now, the technology is still the nascent stages, but scientists have high hopes. In the future, you could wear a temporary tattoo that would monitor your vital signs, or doctors might install stretchable electronics on your organs to keep track of their behavior. Stretchable electronics could also be integrated into clothing or paired with a smartphone. Of course, if all else fails, it’ll probably make for some great children’s toys.

See@MC10

Via Daily Mail

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A promotional video created to promote the concept shows drinkers entering a bar, and then being offerend cheap drinks as they are recognised.

'Facebook check-ins are a powerful mechanism for businesses to deliver discounts to loyal customers, yet few businesses—and fewer customers—have realized it,' said Nashville-based advertising agency Redpepper.

They are already trialling the scheme in firms close to their office.

'A search for businesses with active deals in our area turned up a measly six offers.

'The odds we’ll ever be at one of those six spots are low (a strip club and photography studio among them), and the incentives for a check-in are not nearly enticing enough for us to take the time.

'So we set out to evolve the check-in and sweeten the deal, making both irresistible.

'We call it Facedeals.'

The Facedeal camera can identify faces when people walk in by comparing Facebook pictures of people who have signed up to the service

Facebook recently hit the headlines when it bought face.com, an Israeli firm that pioneered the use of face recognition technology online.

The social networking giant uses the software to recognise people in uploaded pictures, allowing it to accurately spot friends.

The software uses a complex algorithm to find the correct person from their Facebook pictures

The Facebook camera requires people to have authorised the Facedeals app through their Facebook account.

This verifies your most recent photo tags and maps the biometric data of your face.

The system then learns what a user looks like as more pictures are approved.

This data is then used to identify you in the real world.

In a demonstration video, the firm behind the camera showed it being used to offer free drinks to customers if they signed up to the system.