Computed·Blg

Via FUTURITY

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A medical sensor that attaches to the skin like a temporary tattoo could make it easier for doctors to detect metabolic problems in patients and for coaches to fine-tune athletes’ training routines. And the entire sensor comes in a thin, flexible package shaped like a smiley face. (Credit: University of Toronto)

It looks like a smiley face tattoo, but a new easy-to-apply sensor can detect medical problems and help athletes fine-tune training routines.

“We wanted a design that could conceal the electrodes,” says Vinci Hung, a PhD candidate in physical and environmental sciences at the University of Toronto, who helped create the new sensor. “We also wanted to showcase the variety of designs that can be accomplished with this fabrication technique.”

The tattoo, which is an ion-selective electrode (ISE), is made using standard screen printing technique and commercially available transfer tattoo paper—the same kind of paper that usually carries tattoos of Spiderman or Disney princesses.

In the case of the sensor, the “eyes” function as the working and reference electrodes, and the “ears” are contacts for a measurement device to connect to.

Hung contributed to the work while in the lab of Joseph Wang, a professor at the University of California, San Diego. The sensor she helped make can detect changes in the skin’s pH levels in response to metabolic stress from exertion.

Similar devices are already used by medical researchers and athletic trainers. They can give clues to underlying metabolic diseases such as Addison’s disease, or simply signal whether an athlete is fatigued or dehydrated during training. The devices are also useful in the cosmetics industry for monitoring skin secretions.

But existing devices can be bulky or hard to keep adhered to sweating skin. The new tattoo-based sensor stayed in place during tests, and continued to work even when the people wearing them were exercising and sweating extensively.

The tattoos were applied in a similar way to regular transfer tattoos, right down to using a paper towel soaked in warm water to remove the base paper.

To make the sensors, Hung and colleagues used a standard screen printer to lay down consecutive layers of silver, carbon fiber-modified carbon and insulator inks, followed by electropolymerization of aniline to complete the sensing surface.

By using different sensing materials, the tattoos can also be modified to detect other components of sweat, such as sodium, potassium, or magnesium, all of which are of potential interest to researchers in medicine and cosmetology.

An article describing the work has been accepted for publication in the journal Analyst.

Via PCWorld

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NEC is working on a suitcase-sized DNA analyzer, which it says will be able to process samples at the scene of a crime or disaster in as little as 25 minutes.

The company said it aims to launch the device globally in 2014, and sell it for around 10 million yen, or US$120,000. It will output samples that can be quickly matched via the growing number of DNA databases worldwide.

“At first we will target investigative organizations, like police,” said spokeswoman Marita Takahashi. “We will also push its use on victims of natural disasters, to quickly match samples from siblings and parents.”

NEC hopes to use research and software from its mature fingerprint and facial matching technology, which have been deployed in everyday devices such as smartphones and ATMs.

The company said that the need for cheaper and faster DNA testing became clear in the aftermath of the Tohoku earthquake and tsunami that devasted much of Japan’s northeast coastline last year, when authorities performed nearly 20,000 samples.

NEC pointed to growing databases such as CODIS (Combined DNA Index System) in the U.S. and a Japanese database of DNA samples.

The company said it is aiming to make the device usable for those with minimal training, requiring only a cotton swab or small blood sample. NEC aims to make a device that weighs around 35 kilograms, measuring 850 millimeters by 552mm by 240mm, about the size of a large suitcase. The unit will run on a 12V power source.

NEC said it will be able to complete three-stage analysis process using a “lab on a chip” process, a term for for technology that recreates lab processes on chip-sized components. The basic steps for analysis include extracting DNA from samples, amplifying the DNA for analysis, and then separating out the different DNA strands.

The current version of the analyzer takes about an hour for all three tasks, and NEC said it aims to lower that to 25 minutes.

NEC it is carrying out the development of the analyzer together with partners including Promega, a U.S. biotechnology firm, and is testing it with a police science research institute in Japan.

Via Life Hacker

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Via BBC

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Governments around the world made nearly 21,000 requests for access to Google data in the first six months of this year, according to the search engine.

Its Transparency Reportindicates government surveillance of online lives is rising sharply.

The US government made the most demands, asking for details 7,969 times in the first six months of 2012.

Turkey topped the list for requests to remove content.

Government 'bellwether'

Google, in common with other technology and communication companies, regularly receives requests from government agencies and courts around the world to have access to content.

It has been publishing its Transparency Report twice a year since 2009 and has seen a steady rise in government demands for data. In its first report in 2009, it received 12,539 requests. The latest figure stands at 20,939.

"This is the sixth time we've released this data, and one trend has become clear: government surveillance is on the rise," Google said in a blog post.

The report acts as a bellwether for government behaviour around the world, a Google spokeswoman told the BBC.

"It reflects laws on the ground. For example in Turkey there are specific laws about defaming public figures whereas in Germany we get requests to remove neo-Nazi content," she said.

"And in Brazil we get a lot of requests to remove content during elections because there is a law banning parodies of candidates.

"We hope that the report will shed light on how governments interact with online services and how laws are reflected in online behaviour," she added.

The US has consistently topped the charts for data requests. France, Germany, Italy, Spain and the UK are also in the top 10.

In France and Germany it complied with fewer than half of all requests. In the UK it complied with 64% of requests and 90% of requests from the US.

Removing content

Google said the top three reasons cited by government for content removal were defamation, privacy and security.

Worldwide authorities made 1,789 requests for Google to remove content, up from 1,048 requests for the last six months of 2011.

In the period from January to June, Turkey made 501 requests for content removal.

These included 148 requests related to Mustafa Kemal Ataturk - the first president of Turkey, the current government, national identity and values.

Others included claims of pornography, hate speech and copyright.

Google has its own criteria for whether it will remove content - the request must be specific, relate to a specific web address and have come from a relevant authority.

In one example from the UK, Google received a request from police to remove 14 search results that linked to sites allegedly criticising the police and claiming individuals were involved in obscuring crimes. It did not remove the content.

Via c|net

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Security cameras that watch you, and predict what you'll do next, sound like science fiction. But a team from Carnegie Mellon University says their computerized surveillance software will be capable of "eventually predicting" what you're going to do.

Computerized surveillance can predict what people will do next -- it's called "activity forecasting" -- and eventually sound the alarm if the action is not permitted. Click for larger image.

(Credit: Carnegie Mellon University)

Computer software programmed to detect and report illicit behavior could eventually replace the fallible humans who monitor surveillance cameras.

The U.S. government has funded the development of so-called automatic video surveillance technology by a pair of Carnegie Mellon University researchers who disclosed details about their work this week -- including that it has an ultimate goal of predicting what people will do in the future.

"The main applications are in video surveillance, both civil and military," Alessandro Oltramari, a postdoctoral researcher at Carnegie Mellon who has a Ph.D. from Italy's University of Trento, told CNET yesterday.

Oltramari and fellow researcher Christian Lebiere say automatic video surveillance can monitor camera feeds for suspicious activities like someone at an airport or bus station abandoning a bag for more than a few minutes. "In this specific case, the goal for our system would have been to detect the anomalous behavior," Oltramari says.

Think of it as a much, much smarter version of a red light camera: the unblinking eye of computer software that monitors dozens or even thousands of security camera feeds could catch illicit activities that human operators -- who are expensive and can be distracted or sleepy -- would miss. It could also, depending on how it's implemented, raise similar privacy and civil liberty concerns.

Alessandro Oltramari, left, and Christian Lebiere say their software will "automatize video-surveillance, both in military and civil applications."

(Credit: Carnegie Mellon University)

A paper (PDF) the researchers presented this week at the Semantic Technology for Intelligence, Defense, and Security conference outside of Washington, D.C. -- today's sessions are reserved only for attendees with top secret clearances -- says their system aims "to approximate human visual intelligence in making effective and consistent detections."

Their Army-funded research, Oltramari and Lebiere claim, can go further than merely recognizing whether any illicit activities are currently taking place. It will, they say, be capable of "eventually predicting" what's going to happen next.

This approach relies heavily on advances by machine vision researchers, who have made remarkable strides in last few decades in recognizing stationary and moving objects and their properties. It's the same vein of work that led to Google's self-driving cars, face recognition software used on Facebook and Picasa, and consumer electronics like Microsoft's Kinect.

When it works well, machine vision can detect objects and people -- call them nouns -- that are on the other side of the camera's lens.

But to figure out what these nouns are doing, or are allowed to do, you need the computer science equivalent of verbs. And that's where Oltramari and Lebiere have built on the work of other Carnegie Mellon researchers to create what they call a "cognitive engine" that can understand the rules by which nouns and verbs are allowed to interact.

Their cognitive engine incorporates research, called activity forecasting, conducted by a team led by postdoctoral fellow Kris Kitani, which tries to understand what humans will do by calculating which physical trajectories are most likely. They say their software "models the effect of the physical environment on the choice of human actions."

Both projects are components of Carnegie Mellon's Mind's Eye architecture, a DARPA-created project that aims to develop smart cameras for machine-based visual intelligence.

Predicts Oltramari: "This work should support human operators and automatize video-surveillance, both in military and civil applications."

Via Slash Gear

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European data protection regulators have demanded Google change its privacy policy, though the French-led team did not conclude that the search giant’s actions amounted to something illegal. The investigation, by the Commission Nationale de l’Informatique (CNIL), argued that Google’s decision to condense the privacy policies of over sixty products into a single agreement – and at the same time increase the amount of inter-service data sharing – could leave users unclear as to how different types of information (as varied as search terms, credit card details, or phone numbers) could be used by the company.

“The Privacy Policy makes no difference in terms of processing between the innocuous content of search query and the credit card number or the telephone communications of the user” the CNIL points out, “all these data can be used equally for all the purposes in the Policy.” That some web users merely interact passively with Google products, such as adverts, also comes in for heightened attention, with those users getting no explanation at all as to how their actions might be tracked or stored.

“EU Data protection authorities ask Google to provide clearer and more comprehensive information about the collected data and purposes of each of its personal data processing operations. For instance, EU Data protection authorities recommend the implementation of a presentation with three levels of detail to ensure that information complies with the requirements laid down in the Directive and does not degrade the users’ experience. The ergonomics of the Policy could also be improved with interactive presentations” CNIL

In a letter to Google [pdf link] – signed by the CNIL and other authorities from across Europe – the concerns are laid out in full, together with some suggestions as to how they can be addressed. For instance, the search company could “develop interactive presentations that allow users to navigate easily through the content of the policies” and “provide additional and precise information about data that have a significant impact on users (location, credit card data, unique device identifiers, telephony, biometrics).”

Ironically, one of Google’s arguments for initially changing its policy system was that a single, harmonized agreement would be easier for users to read through and understand. It also insisted that the data-sharing aspects were little changed from before.

“The CNIL, all the authorities among the Working Party and data protection authorities from other regions of the world expect Google to take effective and public measures to comply quickly and commit itself to the implementation of these recommendations” the commission concluded. Google has a 3-4 month period to enact the changes requested, or it could face the threat of sanctions.

“We have received the report and are reviewing it now” Peter Fleischer, Google’s global privacy counsel, told TechCrunch. “Our new privacy policy demonstrates our long-standing commitment to protecting our users’ information and creating great products. We are confident that our privacy notices respect European law.”

Via PLOS genetics

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Abstract

Inter-individual variation in facial shape is one of the most noticeable phenotypes in humans, and it is clearly under genetic regulation; however, almost nothing is known about the genetic basis of normal human facial morphology. We therefore conducted a genome-wide association study for facial shape phenotypes in multiple discovery and replication cohorts, considering almost ten thousand individuals of European descent from several countries. Phenotyping of facial shape features was based on landmark data obtained from three-dimensional head magnetic resonance images (MRIs) and two-dimensional portrait images. We identified five independent genetic loci associated with different facial phenotypes, suggesting the involvement of five candidate genes—PRDM16, PAX3, TP63, C5orf50, and COL17A1—in the determination of the human face. Three of them have been implicated previously in vertebrate craniofacial development and disease, and the remaining two genes potentially represent novel players in the molecular networks governing facial development. Our finding at PAX3 influencing the position of the nasion replicates a recent GWAS of facial features. In addition to the reported GWA findings, we established links between common DNA variants previously associated with NSCL/P at 2p21, 8q24, 13q31, and 17q22 and normal facial-shape variations based on a candidate gene approach. Overall our study implies that DNA variants in genes essential for craniofacial development contribute with relatively small effect size to the spectrum of normal variation in human facial morphology. This observation has important consequences for future studies aiming to identify more genes involved in the human facial morphology, as well as for potential applications of DNA prediction of facial shape such as in future forensic applications.

Introduction

The morphogenesis and patterning of the face is one of the most complex events in mammalian embryogenesis. Signaling cascades initiated from both facial and neighboring tissues mediate transcriptional networks that act to direct fundamental cellular processes such as migration, proliferation, differentiation and controlled cell death. The complexity of human facial development is reflected in the high incidence of congenital craniofacial anomalies, and almost certainly underlies the vast spectrum of subtle variation that characterizes facial appearance in the human population.

Facial appearance has a strong genetic component; monozygotic (MZ) twins look more similar than dizygotic (DZ) twins or unrelated individuals. The heritability of craniofacial morphology is as high as 0.8 in twins and families [1], [2], [3]. Some craniofacial traits, such as facial height and position of the lower jaw, appear to be more heritable than others [1], [2], [3]. The general morphology of craniofacial bones is largely genetically determined and partly attributable to environmental factors [4]–[11]. Although genes have been mapped for various rare craniofacial syndromes largely inherited in Mendelian form [12], the genetic basis of normal variation in human facial shape is still poorly understood. An appreciation of the genetic basis of facial shape variation has far reaching implications for understanding the etiology of facial pathologies, the origin of major sensory organ systems, and even the evolution of vertebrates [13], [14]. In addition, it is feasible to speculate that once the majority of genetic determinants of facial morphology are understood, predicting facial appearance from DNA found at a crime scene will become useful as investigative tool in forensic case work [15]. Some externally visible human characteristics, such as eye color [16]–[18] and hair color [19], can already be inferred from a DNA sample with practically useful accuracies.

In a recent candidate gene study carried out in two independent European population samples, we investigated a potential association between risk alleles for non-syndromic cleft lip with or without cleft palate (NSCL/P) and nose width and facial width in the normal population [20]. Two NSCL/P associated single nucleotide polymorphisms (SNPs) showed association with different facial phenotypes in different populations. However, facial landmarks derived from 3-Dimensional (3D) magnetic resonance images (MRI) in one population and 2-Dimensional (2D) portrait images in the other population were not completely comparable, posing a challenge for combining phenotype data. In the present study, we focus on the MRI-based approach for capturing facial morphology since previous facial imaging studies by some of us have demonstrated that MRI-derived soft tissue landmarks represent a reliable data source [21], [22].

In geometric morphometrics, there are different ways to deal with the confounders of position and orientation of the landmark configurations, such as (1) superimposition [23], [24] that places the landmarks into a consensus reference frame; (2) deformation [25]–[27], where shape differences are described in terms of deformation fields of one object onto another; and (3) linear distances [28], [29], where Euclidean distances between landmarks instead of their coordinates are measured. Rationality and efficacy of these approaches have been reviewed and compared elsewhere [30]–[32]. We briefly compared these methods in the context of our genome-wide association study (GWAS) (see Methods section) and applied them when appropriate.

We extracted facial landmarks from 3D head MRI in 5,388 individuals of European origin from Netherlands, Australia, and Germany, and used partial Procrustes superimposition (PS) [24], [30], [33] to superimpose different sets of facial landmarks onto a consensus 3D Euclidean space. We derived 48 facial shape features from the superimposed landmarks and estimated their heritability in 79 MZ and 90 DZ Australian twin pairs. Subsequently, we conducted a series of GWAS separately for these facial shape dimensions, and attempted to replicate the identified associations in 568 Canadians of European (French) ancestry with similar 3D head MRI phenotypes and additionally sought supporting evidence in further 1,530 individuals from the UK and 2,337 from Australia for whom facial phenotypes were derived from 2D portrait images.

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The full article@PLOS genetics

Via Motherboard

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Wearable computing is all the rage this year as Google pulls back the curtain on their Glass technology, but some scientists want to take the idea a stage further. The emerging field of stretchable electronics is taking advantage of new polymers that allow you to not just wear your computer but actually become a part of the circuitry. By embedding the wiring into a stretchable polymer, these cutting edge devices resemble human skin more than they do circuit boards. And with a whole host of possible medical uses, that’s kind of the point.

A Cambridge, Massachusetts startup called MC10 is leading the way in stretchable electronics. So far, their products are fairly simple. There’s a patch that’s meant to be installed right on the skin like a temporary tattoo that can sense whether or not the user is hydrated as well as an inflatable balloon catheter that can measure the electronic signals of the user’s heartbeat to search for irregularities like arrythmias. Later this year, they’re launching a mysterious product with Reebok that’s expected to take advantage of the technology’s ability to detect not only heartbeat but also respiration, body temperature, blood oxygenation and so forth.

The joy of stretchable electronics is that the manufacturing process is not unlike that of regular electronics. Just like with a normal microchip, gold electrodes and wires are deposited on to thin silicone wafers, but they’re also embedded in the stretchable polymer substrate. When everything’s in place, the polymer substrate with embedded circuitry can be peeled off and later installed on a new surface. The components that can be added to stretchable surface include sensors, LEDs, transistors, wireless antennas and solar cells for power.

For now, the technology is still the nascent stages, but scientists have high hopes. In the future, you could wear a temporary tattoo that would monitor your vital signs, or doctors might install stretchable electronics on your organs to keep track of their behavior. Stretchable electronics could also be integrated into clothing or paired with a smartphone. Of course, if all else fails, it’ll probably make for some great children’s toys.

See@MC10

Via Daily Mail

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A promotional video created to promote the concept shows drinkers entering a bar, and then being offerend cheap drinks as they are recognised.

'Facebook check-ins are a powerful mechanism for businesses to deliver discounts to loyal customers, yet few businesses—and fewer customers—have realized it,' said Nashville-based advertising agency Redpepper.

They are already trialling the scheme in firms close to their office.

'A search for businesses with active deals in our area turned up a measly six offers.

'The odds we’ll ever be at one of those six spots are low (a strip club and photography studio among them), and the incentives for a check-in are not nearly enticing enough for us to take the time.

'So we set out to evolve the check-in and sweeten the deal, making both irresistible.

'We call it Facedeals.'

The Facedeal camera can identify faces when people walk in by comparing Facebook pictures of people who have signed up to the service

Facebook recently hit the headlines when it bought face.com, an Israeli firm that pioneered the use of face recognition technology online.

The social networking giant uses the software to recognise people in uploaded pictures, allowing it to accurately spot friends.

The software uses a complex algorithm to find the correct person from their Facebook pictures

The Facebook camera requires people to have authorised the Facedeals app through their Facebook account.

This verifies your most recent photo tags and maps the biometric data of your face.

The system then learns what a user looks like as more pictures are approved.

This data is then used to identify you in the real world.

In a demonstration video, the firm behind the camera showed it being used to offer free drinks to customers if they signed up to the system.

Via The Laboratorium

By James Grimmelmann
Professor of Law

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